Regioselective Reductive Coupling of Alkynes and Aldehydes Leading to Allylic Alcohols
Kazuhiko Takai,* Shuji Sakamoto and Takahiko Isshiki
*Department of Applied Chemistry, Faculty of Engineering, Okayama
University, Tsushima, Okayama 700-8530, Japan, Email: ktakai
cc.okayama-u.ac.jp
K. Takai, S. Sakamoto, T. Isshiki, Org. Lett., 2003, 5, 653-655.
DOI: 10.1021/ol0272996
Abstract
Slow addition of a terminal alkyne and water to a mixture of an aldehyde, CrCl2, NiCl2 and a catalytic amount of triphenylphosphine in DMF at 25°C generates a 1,2-disubstituted allylic alcohol regioselectively.
see
article for more examples
Key Words
Alkynes, Coupling, Allylic Alcohols, Chromium Compounds
ID: J54-Y2003-370
