Regioselective Reductive Coupling of Alkynes and Aldehydes Leading to Allylic Alcohols
Kazuhiko Takai,* Shuji Sakamoto and Takahiko Isshiki
*Department of Applied Chemistry, Faculty of Engineering, Okayama University, Tsushima, Okayama 700-8530, Japan, Email: ktakaicc.okayama-u.ac.jp
K. Takai, S. Sakamoto, T. Isshiki, Org. Lett., 2003, 5, 653-655.
Slow addition of a terminal alkyne and water to a mixture of an aldehyde, CrCl2, NiCl2 and a catalytic amount of triphenylphosphine in DMF at 25°C generates a 1,2-disubstituted allylic alcohol regioselectively.
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Alkynes, Coupling, Allylic Alcohols, Chromium Compounds