Copper(II)-Catalyzed Ether Synthesis from Aliphatic Alcohols and Potassium Organotrifluoroborate Salts
Tan D. Quach and Robert A. Batey*
*Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada, Email: rbateychem.utoronto.ca
T. D. Quach, R. A. Batey, Org. Lett., 2003, 5, 1381-1384.
DOI: 10.1021/ol034454n (free Supporting Information)
A protocol for the copper(II)-catalyzed etherification of aliphatic primary and secondary alcohols and phenols with air- and moisture-stable potassium alkenyl- and aryltrifluoroborate salts utilizes a catalytic amount of copper(II) acetate with 4-(dimethylamino)pyridine as ligand in presence of 4 Å molecular sieves under an atmosphere of oxygen.
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