Influence of HMPA on Reducing Power and Reactivity of SmBr2
Brian W. Knettle and Robert A. Flowers, II*
*Department of Chemistry, University of Toledo, Toledo, Ohio 43606, Email: rfloweruoft02.utoledo.edu
B. W. Knettle, R. A. Flowers, II, Org. Lett., 2001, 3, 2321-2324.
DOI: 10.1021/ol0160957 (free Supporting Information)
The combination of HMPA and SmBr2 in THF is a powerful reductant that is capable of reducing ketimines and alkyl chlorides at room temperature. The structure of this reductant has not been established.
see article for more reactions
low-valent samarium reagents, reduction of imines, dehalogenation