Influence of HMPA on Reducing Power and Reactivity of SmBr₂

Brian W. Knettle and Robert A. Flowers, II*

*Department of Chemistry, University of Toledo, Toledo, Ohio 43606, Email: rfloweruoft02.utoledo.edu

B. W. Knettle, R. A. Flowers, II, Org. Lett., 2001, 3, 2321-2324.

DOI: 10.1021/ol0160957 (free Supporting Information)

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Abstract

The combination of HMPA and SmBr₂ in THF is a powerful reductant that is capable of reducing ketimines and alkyl chlorides at room temperature. The structure of this reductant has not been established.

see article for more reactions

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Key Words

low-valent samarium reagents, reduction of imines, dehalogenation

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ID: J54-Y2001-300