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A Novel Catalytic Three-Component Synthesis (Kabachnick-Fields Reaction) of α-Aminophosphonates from Ketones

Elena D. Matveeva, Tatyana A. Podrugina, Elena V. Tishkovskaya, Larisa G. Tomilova, Nikolay S. Zefirov*

*Department of Chemistry, Moscow Lomonosov University, Moscow, Russia, Email:

E. D. Matveeva, T. A. Podrugina, E. V. Tishkovskaya, L. G. Tomilova, N. S. Zefirov, Synlett, 2003, 2321-2324.

DOI: 10.1055/s-2003-42118

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A highly convenient catalytic variant of the Kabachnik-Fields reaction of ketones, diethylphosphite and either benzylamine or ammonium carbonate in the presence of tetra-tert-butylphthalocyanines affords α-aminophosphonates in acceptable yields for various ketones, including cyclic, sterically hindered and cage ketones.

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Key Words

α-amino phosphonates, catalysis, tetra-tert-butylphtalocyanines, ketones, α-aminophosphonic acids, Kabachnik-Fields Reaction

ID: J60-Y2003-450