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Sonogashira Coupling Reaction with Diminished Homocoupling

Arumugasamy Elangovan, Yu-Hsiang Wang and Tong-Ing Ho*

*Department of Chemistry, National Taiwan University, Taipei 106, Taiwan R.O.C., Email:

A. Elangovan, Y.-H. Wang, T.-I. Ho, Org. Lett., 2003, 5, 1841-1844.

DOI: 10.1021/ol034320+ (free Supporting Information)

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The homocoupling reaction of two terminal acetylenes in the Sonogashira reaction can be reduced to about 2% of side product using an atmosphere of hydrogen gas and nitrogen or argon. Terminal arylethynes, diarylethynes, and a few new arylpyridylethynes with donor substituents have been synthesized in excellent yields.

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Key Words

Sonogashira Coupling

ID: J54-Y2003-510