Two effective procedures for the synthesis of trichloromethyl ketones, useful precursors of chiral α-amino and α-hydroxy acids
E. J. Corey, John O. Link and Yang Shao
*Department of Chemistry and Chemical Biology, Harvard
University, Cambridge, Massachusetts, 02138, Email: corey
chemistry.harvard.edu
E. J. Corey, J. O. Link, Y. Shao, Tetrahedron Lett., 1992, 33, 3435-3438.
DOI: 10.1016/S0040-4039(00)92656-X
see article for more examples
Abstract
Trihaloacetic acids can been converted to trichloromethyl and tribromomethyl ketones in good yield by a catalyzed reaction with aldehydes followed by oxidation. A coupling of organozinc intermediates with trichloroacetyl chloride gives trichloromethyl ketones.
see article for more reactions
see article for more examples
Key Words
trichloromethyl carbinols, tribromomethyl carbinols, chromic acid, ketones
ID: J72-Y1992-610
