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R3Al-R'3SiOTf: Novel and Powerful Reagent System for Stereospecific Alkylation-Silylation Reactions of Epoxides

Ponnusamy Shanmugam and Masaaki Miyashita*

*Division of Chemistry, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan, Email:

P. Shanmugam, M. Miyashita, Org. Lett., 2003, 3265-3268.

DOI: 10.1021/ol035075x (free Supporting Information)


A one-pot alkylation-silylation reaction of various epoxides with R3Al-R'3SiOTf occurs stereospecifically to give the corresponding alkylation-silylation products in excellent yields.

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Key Words

epoxides, alkylation, silylation

ID: J54-Y2003-530