An Improved Protocol for the RuO₄-Catalyzed Dihydroxylation of Olefins

Bernd Plietker* and Meike Niggemann

*Institut für Organische Chemie, Universität Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart, Germany, Email: bernd.plietkeroc.uni-stuttgart.de

B. Plietker, M. Niggemann, Org. Lett., 2003, 3353-3356.

DOI: 10.1021/ol035335a

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Abstract

An improved protocol for the RuO₄-catalyzed syn-dihydroxylation uses only 0.5 mol% catalyst under acidic conditions. Various olefins can be hydroxylated in good to excellent yields with only minor formation of side products.

see article for more examples

proposed mechanism

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The acid accelerated ruthenium-catalysed dihydroxylation. Scope and limitations

B. Plietker, M. Niggemann, A. Pollrich, Org. Biomol. Chem., 2004, 2, 1116-1124. DOI: 10.1039/b316546a

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Key Words

Dihydroxylation, Ruthenium, Sodium Periodat

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ID: J54-Y2003-540