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A general, catalytic, and enantioselective synthesis of α-amino acids

E. J. Corey* and John O. Link

*Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, Email:

E. J. Corey, J. O. Link, J. Am. Chem. Soc., 1992, 114, 1906-1908.

DOI: 10.1021/ja00031a069


A novel enantioselective synthesis of α-amino acids has been developed, which is broad in scope, simple in application, and advantageous for many α-amino acids of interest in chemistry, biology, medicine.

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Key Words

Corey-Bakshi-Shibata Reduction, Jocic Reaction, Azides, Reduction of Azides, α-Amino Acids, Catecholborane, Hydrogen

ID: J48-Y1992-190