Rapid and Efficient Microwave-Assisted Amination of Electron-Rich Aryl Halides without a Transition-Metal Catalyst
Lei Shi, Min Wang, Chun-An Fan, Fu-Min Zhang and Yong-Qiang Tu*
*Department of Chemistry & State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China, Email: tuyqlzu.edu.cn
L. Shi, M. Wang, C.-A. Fan, F.-M. Zhang, Y.-Q. Tu, Org. Lett., 2003, 5, 3515-3517.
DOI: 10.1021/ol0353868 (free Supporting Information)
An efficient, transition metal catalyst-free amination of aryl halides under microwave irradiation is a particularly powerful method for the coupling of electron-rich aryl halides with various amines. Meta-substituted anilines have been prepared from ortho- or para-substituted phenylhalides. A mechanism via a benzyne intermediate has been proposed.
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