A mild and efficient cyanosilylation of ketones catalyzed by a Lewis acid-Lewis base bifunctional catalyst
Yongcun Shen, Xiaoming Feng*, Yan Li, Guolin Zhang and Yaozhong Jiang
*Sichuan Key Laboratory of Green Chemistry and Technology, College of
Chemistry, Sichuan University, Chengdu 610064, People's Republic of, China,
Email: xmfeng
pridns.scu.edu.cn
Y. Shen, X. Feng, Y. Li, G. Zhang, Y. Jiang, Tetrahedron, 2003, 59, 5667-6675.
DOI: 10.1016/S0040-4020(03)00908-6
Abstract
Combinations of N-oxides and Ti(OiPr)4 act as bifunctional catalysts in the cyanosilylation of ketones. The reaction is promoted by the dual action of these new titanium complexes via activation of the ketone by the titanium and of TMSCN by the N-oxide.
see article for more examples
Highly Efficient Double-Activation Catalysts for the Synthesis of Ketone Cyanohydrins
F.-X. Chen, X. Liu, B. Qin, H. Zhou, X. Feng, G. Zhang, Synthesis, 2004, 2266-2272.
Key Words
Lewis acid, Lewis base, catalyst, cyanosilylation, ketone
ID: J72-Y2003-600
