Carbonylative Sonogashira Coupling of Terminal Alkynes with Aqueous Ammonia
Mohamed S. Mohamed Ahmed and Atsunori Mori*
*Chemical Resources Laboratory, Tokyo Institute of Technology, 4259
Nagatsuta, Yokohama 226-8503, Japan, Email: amori
res.titech.ac.jp
M. S. M. Ahmed, A. Mori, Org. Lett., 2003, 5, 3057-3060.
DOI: 10.1021/ol035007a
Abstract
Carbonylative coupling of terminal alkynes with aryliodides in the presence of PdCl2(PPh3)2 as catalyst, 2 eq. of 0.5 M aqueous ammonia, and CO (1 atm) gives the corresponding α,β-alkynyl ketones in good yields.
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Key Words
Carbonylative Coupling, Palladium Catalysis, Multicomponent Reactions, Alkynyl Ketones, Aryl Ketones
ID: J54-Y2003-620
