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A CAN-Induced Cyclodimerization-Ritter Trapping Strategy for the One-Pot Synthesis of 1-Amino-4-aryltetralins from Styrenes

Vijay Nair*, Roshini Rajan and Nigam P. Rath

*Organic Chemistry Division, Regional Research Laboratory (CSIR), Trivandrum, India, and Department of Chemistry, University of Missouri, St. Louis, Missouri 63121, Email:

V. Nair, R. Rajan, N. P. Rath, Org. Lett., 2002, 4, 1575-1577.

DOI: 10.1021/ol0257934


A facile one-pot CAN-induced cyclodimerization of various styrenes in acetonitrile or acrylonitrile gave 1-amino-4-aryltetralin derivatives.

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proposed mechanism

Key Words

Ritter Reaction, Cerium Ammonium Nitrate

ID: J54-Y2002-780