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An efficient method for the conversion of aromatic and aliphatic nitriles to the corresponding N-tert-butyl amides: a modified Ritter reaction

K. Laxma Reddy*

*Process Research and Development, Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492-7660, USA, Email:

K. L. Reddy, Tetrahedron Lett., 2003, 44, 1453-1455.

DOI: 10.1016/S0040-4039(03)00006-6


Aromatic and aliphatic nitriles react with tert-butyl acetate in the presence of a catalytic amount of sulfuric acid to give the corresponding N-tert-butyl amides in excellent yields.

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Key Words

modified Ritter Reaction, nitriles, tert-butyl acetate, N-tert-butyl amides

ID: J72-Y2003-660