Tweaking Copper Hydride (CuH) for Synthetic Gain. A Practical, One-Pot Conversion of Dialkyl Ketones to Reduced Trialkylsilyl Ether Derivatives
Bruce H. Lipshutz,* Christopher C. Caires, Peter Kuipers and Will Chrisman
*Department of Chemistry and Biochemistry, University of California, Santa
Barbara, California 93106, Email: lipshutz
chem.ucsb.edu
B. H. Lipshutz, C. C. Caires, P. Kuipers, W. Chrisman, Org. Lett., 2003, 5, 3085-3088.
DOI: 10.1021/ol035164+
Abstract
Optimizations to generate CuH in situ have led to an efficient and inexpensive hydrosilylation method for dialkyl ketones.
see article for more examples
Copper(I) Hydride-Catalyzed Asymmetric Hydrosilylation of Heteroaromatic Ketones
B. H. Lipshutz, A. Lower, K. Noson, Org. Lett., 2002, 4, 4045-4048.
Key Words
Silyl Ethers, Ketones, Reductions, Copper Hydride, Triethylsilane
ID: J54-Y2003-670
