Organic Chemistry Portal

Abstracts

Search:

Highly Practical and Enantioselective Cu-Catalyzed Conjugate Addition of Alkylzinc Reagents to Cyclic Enones at Ambient Temperature

Isaac J. Krauss and James L. Leighton*

*Department of Chemistry, Columbia University, New York, New York 10027, Email: leightonchem.columbia.edu

I. J. Krauss, J. L. Leighton, Org. Lett., 2003, 5, 3201-3203.

DOI: 10.1021/ol034983r


Abstract

A new, readily to prepare, air-stable, crystalline ligand for Cu-catalyzed enantioselective additions of dialkylzincs to cyclic enones provides optimal performance (good to excellent enantioselectivities) at ambient temperature with a range of substrates.

see article for more examples



Key Words

1,4-addition


ID: J54-Y2003-680