Highly Practical and Enantioselective Cu-Catalyzed Conjugate Addition of Alkylzinc Reagents to Cyclic Enones at Ambient Temperature
Isaac J. Krauss and James L. Leighton*
*Department of Chemistry, Columbia University, New York, New York 10027, Email: leightonchem.columbia.edu
I. J. Krauss, J. L. Leighton, Org. Lett., 2003, 5, 3201-3203.
DOI: 10.1021/ol034983r
Abstract
A new, readily to prepare, air-stable, crystalline ligand for Cu-catalyzed enantioselective additions of dialkylzincs to cyclic enones provides optimal performance (good to excellent enantioselectivities) at ambient temperature with a range of substrates.
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ID: J54-Y2003-680