Beckmann reaction of oximes catalysed by chloral: mild and neutral procedures
Sosale Chandrasekhar* and Kovuru Gopalaiah
*Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India, Email: sosaleorgchem.iisc.ernet.in
S. Chandrasekhar, K. Gopalaiah, Tetrahedron Lett., 2003, 44, 755-756.
Various ketoximes undergo the Beckmann rearrangement when heated with 0.5 molar equiv. of chloral (hydrate) in the absence of solvents and acids. Yields of the corresponding amides were excellent after a simple work-up. Aromatic aldoximes were dehydrated to the corresponding nitriles in excellent yields under similar conditions.
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