Beckmann reaction of oximes catalysed by chloral: mild and neutral procedures
Sosale Chandrasekhar* and Kovuru Gopalaiah
*Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India, Email: sosaleorgchem.iisc.ernet.in
S. Chandrasekhar, K. Gopalaiah, Tetrahedron Lett., 2003, 44, 755-756.
Various ketoximes undergo the Beckmann rearrangement when heated with 0.5 molar equiv. of chloral (hydrate) in the absence of solvents and acids. Yields of the corresponding amides were excellent after a simple work-up. Aromatic aldoximes were dehydrated to the corresponding nitriles in excellent yields under similar conditions.
see article for more examples
see article for more reactions
Beckmann Rearrangement, nitriles, catalytic, chloral, green chemistry