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Synthesis of tertiary α-amino phosphonate by one-pot three-component coupling mediated by LPDE

Najmedin Azizi and Mohammad R. Saidi*

*Department of Chemistry, Sharif University of Technology, P.O. Box 11365-9516, Tehran, Iran, Email:

N. Azizi, M. R. Saidi, Tetrahedron, 2003, 59, 5329-5332.

DOI: 10.1016/S0040-4020(03)00759-2


A new, very mild, efficient and simple method for the preparation of tertiary α-amino phosphonates is reported. The reaction of an aldehyde, a secondary amine and trialkylphosphite in ethereal solution of lithium perchlorate (LPDE) at ambient temperature gives the desired product in high yields.

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Key Words

α-amino phosphonates, trialkylphosphites, lithium perchlorate, Kabachnik-Fields Reaction

ID: J72-Y2003-700