Organic Chemistry Portal



Palladium-Catalyzed, Carboxylic Acid-Assisted Allylic Substitution of Carbon Nucleophiles with Allyl Alcohols as Allylating Agents in Water

Kei Manabe and Shu Kobayashi*

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Email:

K. Manabe, S. Kobayashi, Org. Lett., 2003, 5, 3241-3244.

DOI: 10.1021/ol035126q


A combination of tetrakis(triphenylphosphine)palladium and a carboxylic acid such as 1-adamantanecarboxylic acid allows the allylic substitution of allyl alcohols in an aqueous suspension. Various substrates are applicable to this catalytic system.

see article for more examples

Key Words

allylic substitution

ID: J54-Y2003-740