Palladium-Catalyzed, Carboxylic Acid-Assisted Allylic Substitution of Carbon Nucleophiles with Allyl Alcohols as Allylating Agents in Water
Kei Manabe and Shu Kobayashi*
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Email: skobayasmol.f.u-tokyo.ac.jp
K. Manabe, S. Kobayashi, Org. Lett., 2003, 5, 3241-3244.
DOI: 10.1021/ol035126q
Abstract
A combination of tetrakis(triphenylphosphine)palladium and a carboxylic acid such as 1-adamantanecarboxylic acid allows the allylic substitution of allyl alcohols in an aqueous suspension. Various substrates are applicable to this catalytic system.
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Key Words
ID: J54-Y2003-740