Increasing Rates and Scope of Reactions: Sluggish Amines in Microwave-Heated Aminocarbonylation Reactions under Air
Johan Wannberg and Mats Larhed*
*Department of Organic Pharmaceutical Chemistry, Uppsala University, Biomedical Centre, Box-574, SE-751 23 Uppsala, Sweden, Email matsorgfarm.uu.se
J. Wannberg, M. Larhed, J. Org. Chem., 2003, 68, 5750-5753.
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Molybdenum hexacarbonyl is a convenient and solid carbon monoxide source in a microwave-accelerated palladium-catalyzed aminocarbonylation of aryl bromides and iodides. 16 different aromatic amides were synthesized under air in good yields after only 15 min of controlled microwave irradiation.
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