Increasing Rates and Scope of Reactions: Sluggish Amines in Microwave-Heated Aminocarbonylation Reactions under Air
Johan Wannberg and Mats Larhed*
*Department of Organic Pharmaceutical Chemistry, Uppsala University,
Biomedical Centre, Box-574, SE-751 23 Uppsala, Sweden, Email mats
orgfarm.uu.se
J. Wannberg, M. Larhed, J. Org. Chem., 2003, 68, 5750-5753.
DOI: 10.1021/jo034382d
see article for more reactions
Abstract
Molybdenum hexacarbonyl is a convenient and solid carbon monoxide source in a microwave-accelerated palladium-catalyzed aminocarbonylation of aryl bromides and iodides. 16 different aromatic amides were synthesized under air in good yields after only 15 min of controlled microwave irradiation.
see article for more examples
Key Words
Aminocarbonylation, Microwave Synthesis
ID: J42-Y2003-760
