New Reactions of IBX: Oxidation of Nitrogen- and Sulfur-Containing Substrates To Afford Useful Synthetic Intermediates
K. C. Nicolaou*, Casey J. N. Mathison, Tamsyn Montagnon
*Department of Chemistry and The Skaggs Institute for Chemical Biology, The
Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037,
USA, Email: kcn
scripps.edu
K. C. Nicolaou, C. J. N. Mathison, T. Montagnon, Angew. Chem. Int. Ed., 2003, 42, 4077-4082.
DOI: 10.1002/anie.200352076
Abstract
A number of new reactions of IBX with heteroatom-containing substrates were discovered and their utility was demonstrated. IBX was used for the generation of imines from secondary amines in notably high yields, for the oxidative aromatization of nitrogen heterocycles and for the cleavage of dithianes.
see article for more reactions
Key Words
imines, imidazoles, oxidation, oximes, synthetic methods, IBX, dithianes
ID: J06-Y2003-770
