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Copper-Catalyzed Coupling of Amides and Carbamates with Vinyl Halides

Lei Jiang, Gabriel E. Job, Artis Klapars, and Stephen L. Buchwald*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email:

L. Jiang, G. E. Job, A. Klapars, S. L. Buchwald, Org. Lett., 2003, 5, 3667-3669.

DOI: 10.1021/ol035355c


A versatile and efficient copper-catalyzed amidation of vinyl bromides and iodides has been developed. The protocol, which uses a combination of copper iodide and N,N'-dimethyl ethylenediamine, tolerates substrates bearing ester, silyl ether, and amino groups.

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Key Words

Amides, Carbamates

ID: J54-Y2003-790