Oxone Promoted Nef Reaction. Simple Conversion of Nitro Group into Carbonyl
Paolo Ceccherelli, Massimo Curini, Maria Carla Marcotullio*, Francesco Epifano and Ornelio Rosati
*Diparimento di Chimica e Tecnologia del Farmaco-Sez. Chimica Organica,
Università degli Studi, Via del liceo, 1, 06123 Perugia-Italy, Email:
marcotu
unipg.it
P. Ceccherelli, M. Curini, M. C. Marcotullio, F. Epifano, O. Rosati, Synth. Commun., 1998, 28, 3057-3064.
DOI: 10.1080/00397919808004885
Abstract
A mild and convenient oxidative Nef reaction using Oxone is described. Following this procedure primary and secondary nitroalkanes generates carboxylic acids and ketones, respectively, both in good yields.
see article for more examples
proposed
mechanism
Key Words
Nitro Compounds, Ketones, Nef Reaction, Oxone
ID: JXX-Y1998-230
