A Highly Active and Selective Catalyst System for the Baylis-Hillman Reaction
Jingsong You, Juhua Xu, John G. Verkade*
*Department of Chemistry, Iowa State University, Ames, IA 50011, USA, Email: jverkadeiastate.edu
J. You, J. Xu, J. G. Verkade, Angew. Chem. Int. Ed., 2003, 41, 5054-5066.
A highly active and selective catalyst system for the Baylis-Hillman reaction was developed. The described protocol is applicable to activated alkenes such as enones, acrylonitriles and acrylates.
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Baylis-Hillman Reaction, heterocycles, Lewis bases, titanium