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A Highly Active and Selective Catalyst System for the Baylis-Hillman Reaction

Jingsong You, Juhua Xu, John G. Verkade*

*Department of Chemistry, Iowa State University, Ames, IA 50011, USA, Email:

J. You, J. Xu, J. G. Verkade, Angew. Chem. Int. Ed., 2003, 41, 5054-5066.

DOI: 10.1002/anie.200352233


A highly active and selective catalyst system for the Baylis-Hillman reaction was developed. The described protocol is applicable to activated alkenes such as enones, acrylonitriles and acrylates.

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Key Words

Baylis-Hillman Reaction, heterocycles, Lewis bases, titanium

ID: J06-Y2003-840