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Development of Thiourea-Based Ligands for the Palladium-Catalyzed Bis(methoxycarbonylation) of Terminal Olefins

Mingji Dai, Cuihua Wang, Guangbin Dong, Jing Xiang, Tuoping Luo, Bo Liang, Jiahua Chen, Zhen Yang*

*Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry, Peking University, Beijing, 100871, P. R. China, Email:

M. Dai, C. Wang, G. Dong, J. Xiang, T. Luo, B. Liang, J. Chen, Z. Yang, Eur. J. Org. Chem., 2003, 4346-4348.

DOI: 10.1002/ejoc.200300543


Thiourea-based ligands were evaluated for the palladium-catalyzed bis(methoxycarbonylation) of terminal olefins. The usefulness of these ligands for this reaction is demonstrated by their stability to oxidizing agents, and their superiority in preventing palladium precipitation and double-bond isomerization.

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Key Words

Carboxylation, S ligands, Palladium, Catalysis, O ligands

ID: J24-Y2003-860