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The Aldol Reaction under High-Intensity Ultrasound: A Novel Approach to an Old Reaction

Giancarlo Cravotto*, Alberto Demetri, Gian Mario Nano, Giovanni Palmisano, Andrea Penoni, Silvia Tagliapietra

*Dipartimento di Scienza e Tecnologia del Farmaco, UniversitÓ di Torino, Via Giuria 9, 10125 Torino, Italy, Email:

G. Cravotto, A. Demetri, G. M. Nano, G. Palmisano, A. Penoni, S. Tagliapietra, Eur. J. Org. Chem., 2003, 4438-4444.

DOI: 10.1002/ejoc.200300369


High-intensity ultrasound was employed to reinvestigate the aldol reaction in water. A number of aldols that would eliminate or form side products under conventional conditions were isolated in good yields within minutes. The results are highly reproducible because the sonochemical parameters were rigorously controlled.

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Key Words

aldol reactions, addition, condensation, sonochemistry

ID: J24-Y2003-870