Catalytic, Asymmetric Synthesis of Cyanohydrin Ethyl Carbonates

Yuri N. Belokon, A. John Blacker, Lisa A. Clutterbuck and Michael North*

*Department of Chemistry, King's College London, Strand, London, WC2 R2LS, UK, Email: michael.northkcl.ac.uk

Y. N. Belokon, A. J. Blacker, L. A. Clutterbuck, M. North, Org. Lett., 2003, 5, 4505-4507.

DOI: 10.1021/ol035828f

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Abstract

A bimetallic titanium complex [(salen)TiO]₂ catalyzes the asymmetric addition of ethyl cyanoformate to aldehydes leading to cyanohydrin carbonates with high enantiomeric excesses.

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Key Words

cyanohydrins, carbonates, addition, enantioselective

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ID: J54-Y2003-880