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Titanocene(III)-Promoted Reformatsky Additions

J. D. Parrish, Daniel R. Shelton and R. Daniel Little*

*Department of Chemistry and Biochemistry, University of California-Santa Barbara, Santa Barbara, California 93106-9510, Email:

J. D. Parrish, D. R. Shelton, R. D. Little, Org. Lett., 2003, 5, 3615-3617.

DOI: 10.1021/ol035269c


A novel method for Reformatsky-like reactions employs titanocene(III) chloride as a mild and homogeneous single-electron reductant. The reactions are simple, rapid and tolerate a wide range of functionalities. The addition is anti selective.

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Key Words

Reformatsky Reaction, β-Hydroxy Esters

ID: J54-Y2003-920