A General Method for the Direct α-Arylation of Nitriles with Aryl Chlorides
Jingsong You and John G. Verkade*
*Department of Chemistry, Iowa State University, Ames, IA 50011, USA, Email: jverkadeiastate.edu
J. You, J. G. Verkade, Angew. Chem. Int. Ed., 2003, 42, 5051-5053.
DOI: 10.1002/anie.200351954 (International Edition)
A general method for the direct α-arylation of nitriles with aryl chlorides was developed. With a catalytic system generated from palladium and a commercially available ligand, it is now possible to effect direct α-arylation using a wide variety of starting materials.
see article for more examples