Palladium-Catalyzed Amidation of Enol Triflates: A New Synthesis of Enamides
Debra J. Wallace,* David J. Klauber, Cheng-yi Chen and Ralph P. Volante
*Department of Process Research, Merck Research Laboratories, P. O. Box
2000, Rahway, New Jersey 07065, Email: dwallace
ironwoodpharma.com
D. J. Wallace, D. J. Klauber, C.-Y. Chen, R. P. Volante, Org. Lett., 2003, 5, 4749-4752.
DOI: 10.1021/ol035959g (free Supporting Information)
Abstract
A range of enol triflates can be coupled with amides, carbamates, and sulfonamides using palladium catalysis. This method allows the synthesis of enamides, which may not be readily available by other means.
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Key Words
Amides, Carbamates, Sulfonamides, Enamines
ID: J54-Y2003-1060
