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A Dramatic Effect of Aryloxo Ligands on the Titanium-Catalyzed Hydroamination of Alkynes

Vivek Khedkar, Annegret Tillack and Matthias Beller*

*Leibniz-Institut für Organische Katalyse (IfOK) an der Universität Rostock e.V., Buchbinderstrasse 5-6, D-18055 Rostock, Germany, Email:

V. Khedkar, A. Tillak, M. Beller, Org. Lett., 2003, 5, 4767-4770.

DOI: 10.1021/ol035653+


An aryloxotitanium complex is a highly chemo- and regioselective catalyst for intermolecular hydroamination of terminal alkynes. Branched imines are obtained in good yield with various primary aromatic and aliphatic amines.

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Key Words

Hydroamination, Amines, Reduction, Markovnikov Product, Sodium Cyanoborohydride

ID: J54-Y2003-1090