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A General and Mild Ullmann-Type Synthesis of Diaryl Ethers

Henri-Jean Cristau,* Pascal P. Cellier, Samy Hamada, Jean-Francis Spindler and Marc Taillefer

*Laboratoire de Chimie Organique (CNRS UMR 5076), Ecole Nationale Supérieure de Chimie de Montpellier, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex 5, France, Email:

H.-J. Cristau, P. P. Cellier, S. Hamada, J.-F. Spindler, M. Taillefer, Org. Lett., 2004, 6, 913-916.

DOI: 10.1021/ol036290g (free Supporting Information)


Inexpensive ligands were found to greatly accelerate the Ullmann-type coupling of aryl bromides or iodides with phenols in the presence of Cs2CO3 and catalytic copper(I) oxide. The reaction tolerates sterically hindered coupling partners or electron-rich aryl halides.

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Key Words

Ullmann Ether Synthesis, Ullmann Reaction

ID: J54-Y2004-080