The First Silver-Catalyzed Three-Component Coupling of Aldehyde, Alkyne, and Amine

Chunmei Wei, Zigang Li and Chao-Jun Li*

*Department of Chemistry, McGill University, 801 Sherbrooke St. West, Quebec H3A 2K6 Canada, Email: cj.limcgill.ca

C. Wei, Z. Li, C.-J. Li, Org. Lett., 2003, 5, 4473-4475.

DOI: 10.1021/ol035781y

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Abstract

A three-component coupling between an aldehyde, alkyne and amine is catalyzed by silver iodide to generate propargylic amines in high yields in water without cocatalyst or activator. This method is especially effective for reactions involving aliphatic aldehydes.

see article for more examples

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A Highly Efficient Three-Component Coupling of Aldehyde, Alkyne, and Amines via C-H Activation Catalyzed by Gold in Water

C. Wei, C.-J. Li, J. Am. Chem. Soc., 2003, 125, 9584-9585.

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Key Words

alkynes, multicomponent reactions, propargylamines, green chemistry

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ID: J54-Y2003-1130