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Efficient Hydration of Nitriles to Amides in Water, Catalyzed by Ruthenium Hydroxide Supported on Alumina

Kazuya Yamaguchi, Mitsunori Matsushita, Noritaka Mizuno*

*Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan, Email:

K. Yamaguchi, M. Matsushita, N. Mizuno, Angew. Chem. Int. Ed., 2004, 43, 1576-1580.

DOI: 10.1002/anie.200353461


Ru(OH)x / Al2O3 acts as a heterogeneous catalyst for the hydration of activated and unactivated nitriles in water. This reaction can be performed with high selectivity and conversion to give amides. Furthermore, catalyst/product separation is easy and Ru(OH)x / Al2O3 is recyclable.

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Key Words

amides, hydration, heterogeneous catalysis, ruthenium

ID: J06-Y2004-110