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Phosphane-Catalyzed Knoevenagel Condensation: A Facile Synthesis of α-Cyanoacrylates and α-Cyanoacrylonitriles

Jhillu S. Yadav *, Basi V. Subba Reddy, Ashok K. Basak, Boddapati Visali, Akkirala Venkat Narsaiah, Kommu Nagaiah

*Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad-500 007, India, Email:

J. S. Yadav, B. S. S. Reddy, A. K. Basak, B. Visali, A. V. Narsaiah, K. Nagaiah, Eur. J. Org. Chem., 2004, 546-551.

DOI: 10.1002/ejoc.200300513


Triphenylphosphine is an efficient catalyst for a mild, solvent-free Knoevenagel condensation of aldehydes with ethyl cyanoacetate or malononitrile to afford olefins in excellent yields with (E)-geometry. This method, which is even improved by microwave irradiation, is applicable for a wide range of aldehydes.

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Key Words

Aldehydes, Knoevenagel Condensation, Microwave activation, Phosphanes, Condensation

ID: J24-Y2004-170