Organic Chemistry Portal



Chemoselective Acylation of Amines in Aqueous Media

Sarala Naik, Gitalee Bhattacharjya, Bandana Talukdar, Bhisma K. Patel*

*Indian Institute of Technology, Guwahati, Guwahati 781 039, Assam, India, Email:

S. Naik, G. Bhattacharjya, B. Talukdar, B. K. Patel, Eur. J. Org. Chem., 2004, 1254-1260.

DOI: 10.1002/ejoc.200300620


Amines are efficiently acylated by both cyclic and acyclic anhydrides in aqueous medium with sodium dodecyl sulfate (SDS) - without use of acidic or basic reagents. Various amines and anhydrides were reacted with equal ease. Chemoselective acylation in the presence of phenols and thiols has been achieved. No chromatographic separation is required for isolation of the acylated products.

see article for more examples

Key Words

Amines, Amides, Acylation, Aqueous media, Chemoselectivity, Green Chemistry

ID: J24-Y2004-180