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Montmorillonite KSF clay catalyzed one-pot synthesis of α-aminonitriles

J. S. Yadav*, B. V. Subba Reddy, B. Eeshwaraiah and M. Srinivas

*Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Email:

J. S. Yadav, B. V. S. Reddy, B. Eeshwaraiah, M. Srinivas, Tetrahedron, 2004, 60, 1767-1771.

DOI: 10.1016/j.tet.2003.12.043


Aryl imines, formed in situ from aldehydes and amines undergo mild nucleophilic addition with trimethylsilyl cyanide on the surface of montmorillonite KSF clay to afford the corresponding α-aminonitriles in excellent yields. The solid acid can be recovered and recycled in subsequent reactions with a gradual decrease of activity.

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Key Words

Solid acids, Aryl imines, Trimethylsilyl cyanide, α-Aminonitriles, Strecker Synthesis

ID: J72-Y2004-280