Catalytic Diastereoselective Reductive Claisen Rearrangement
Steven P. Miller and James P. Morken*
*Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, Email: morkenbc.edu
S. P. Miller, J. P. Morken, Org. Lett., 2002, 4, 2743-2745.
DOI: 10.1021/ol026273b (free Supporting Information)
An ester enolate Claisen rearrangement is catalyzed by [(cod)RhCl]2 and MeDuPhos with good yields and diastereocontrol. The mild reaction conditions tolerate base-sensitive functionalities.
see article for more examples
Ireland-Claisen Rearrangement, Silanes