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A Mild Method for the Preparation of γ-Hydroxy-α,β-Acetylenic Esters

Shatrughan P. Shahi, Kazunori Koide*

*Department of Chemistry, University of Pittsburgh, 219 Parkman Avenue, Pittsburgh, PA 15260, USA, Email: koidepitt.edu

S. P. Shani, K. Koide, Angew. Chem. Int. Ed., 2004, 43, 2525-2527.

DOI: 10.1002/anie.200353400 (free Supporting Information)


Abstract

A new method for the coupling of aldehydes or ketones with alkynyl propiolates in the absence of a base was developed. The reagents involved in this coupling reaction are easy to handle and tolerate various functional groups.


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Key Words

alcohols, aldehydes, alkynylation, silver, zirconium


ID: J06-Y2004-290