Preparation of Substituted Piperazinones via Tandem Reductive Amination-(N,N'-Acyl Transfer)-Cyclization
Douglas C. Beshore* and Christopher J. Dinsmore
*Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, Email: douglas_beshoremerck.com
D. C. Beshore, C. J. Dinsmore, Org. Lett., 2002, 4, 1201-1204.
DOI: 10.1021/ol025644l
Abstract
A one-pot, tandem reductive amination-transamidation-cyclization reaction produces substituted piperazin-2-ones in good yields.
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reaction pathway
Key Words
Reductive Amination, Transamidation, Sodium Triacetoxyborohydride
ID: J54-Y2002-880