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A LiCl-Mediated Br/Mg Exchange Reaction for the Preparation of Functionalized Aryl- and Heteroarylmagnesium Compounds from Organic Bromides

Arkady Krasovskiy and Paul Knochel*

*Ludwig Maximilians-Universität München, Department Chemie, Butenandtstrasse 5-13, Haus F, 81377 München, Germany, Email:

A. Krasovski, P. Knochel, Angew. Chem. Int. Ed., 2004, 43, 3333-3336.

DOI: 10.1002/anie.200454084 (free Supporting Information)


iPrMgCl·LiCl can be used for a simple, high-yielding preparation of a broad range of functionalized aryl- and heteroarylmagnesium reagents from aryl bromides. All reactions proceed within a convenient range of temperatures (-15°C - r.t.) and can be extended to the large-scale preparation of Grignard reagents.

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Key Words

C-C coupling, copper, cross-coupling, Grignard Reaction, heterocycles

ID: J06-Y2004-410