A LiCl-Mediated Br/Mg Exchange Reaction for the Preparation of Functionalized Aryl- and Heteroarylmagnesium Compounds from Organic Bromides
Arkady Krasovskiy and Paul Knochel*
*Ludwig Maximilians-Universität München, Department Chemie, Butenandtstrasse
5-13, Haus F, 81377 München, Germany, Email: paul.knochel
cup.uni-muenchen.de
A. Krasovski, P. Knochel, Angew. Chem. Int. Ed., 2004, 43, 3333-3336.
DOI: 10.1002/anie.200454084
Abstract
iPrMgCl·LiCl can be used for a simple, high-yielding preparation of a broad range of functionalized aryl- and heteroarylmagnesium reagents from aryl bromides. All reactions proceed within a convenient range of temperatures (-15°C - r.t.) and can be extended to the large-scale preparation of Grignard reagents.
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Key Words
C-C coupling, copper, cross-coupling, Grignard Reaction, heterocycles
ID: J06-Y2004-410
