Tetraphosphine/palladium catalysed Suzuki cross-coupling reactions of aryl halides with alkylboronic acids

Isabelle Kondolff , Henri Doucet* and Maurice Santelli

*Laboratoire de Synthèse Organique associé au CNRS UMR 6180, Faculté des Sciences de Saint Jérôme, Avenue Escadrille Normandie-Niemen, 13397, Marseille Cedex 20, France, Email: henri.doucetuniv.u-3mrs.fr

I. Kondolff, H. Doucet, M. Santelli, Tetrahedron, 2004, 60, 3813-3818.

DOI: 10.1016/j.tet.2004.03.009

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Abstract

The use of [PdCl(C₃H₅)]₂/cis,cis,cis-1,2,3,4-tetrakis(diphenylphosphinomethyl)cyclopentane as a catalyst allows the Suzuki coupling of a range of aryl bromides and chlorides with alkylboronic acids in good yields. The functional group tolerance on the aryl halide is remarkable. Furthermore, this catalyst can be used at low loading, even for reactions of sterically hindered aryl bromides.

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Key Words

Catalysis, Palladium, Tetraphosphine, Alkylboronic acids, Aryl halides, Suzuki Coupling, Arenes

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ID: J72-Y2004-460