Organic Chemistry Portal



A Straightforward and Mild Synthesis of Functionalized 3-Alkynoates

Andrés Suárez, Gregory C. Fu*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA, Email:

A. Suárez, G. C. Fu, Angew. Chem. Int. Ed., 2004, 43, 3580-3582.

DOI: 10.1002/anie.200454070 (free Supporting Information)


A general, inexpensive, copper-catalyzed coupling of terminal alkynes with diazo compounds provides ready access to 3-alkynoates. This reaction proceeds efficiently under nonbasic conditions at room temperature and tolerates various functional groups.

see article for more examples

Key Words

alkynes, carboxylic compounds, copper, diazo compounds, homogeneous catalysis

ID: J06-Y2004-490