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A Silver-Catalyzed Intramolecular Amidation of Saturated C-H Bonds

Yong Cui, Chuan He*

*Department of Chemistry, University of Chicago, 5735 S. Ellis Avenue, Chicago, IL 60637, USA, Email:

Y. Cui, C. He, Angew. Chem. Int. Ed., 2004, 43, 4210-4212.

DOI: 10.1002/anie.200454243 (free Supporting Information)


An efficient amidation reaction of saturated C-H bonds catalyzed by a unique disilver(I) complex is reported. The reaction is stereospecific and practical for the construction of amine-containing molecules.

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Key Words

amidation, C-H activation, homogeneous catalysis, silver, synthetic methods, protected primary amines, sulfonamides, sultams

ID: J06-Y2004-520