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A Polymer-Supported Phosphoramide as a Lewis-Base Catalyst for the Catalytic Aldol Reaction

Robert A. Flowers II*, Xin Xu, Cody Timmons, Guigen Li

*Department of Chemistry, Lehigh University, Bethlehem, PA 18015, USA, Email:

R. A. Flowers II, X. Xu, C. Timmons, G. Li, Eur. J. Org. Chem., 2004, 2988-2990.

DOI: 10.1002/ejoc.200400228 (free Supporting Information)


Aldol reactions between trichlorosilyl enol ethers and aldehydes were catalyzed by an environmentally benign polymer-supported phosphoramide organocatalyst with significant rate enhancements. Eight examples are reported with moderate to good chemical yields and stereoselectivity.

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Key Words

HMPA-type derivative, Aldol reactions, Polymeric phosphoramide, Mukaiyama Aldol Addition, Organocatalysis

ID: J24-Y2004-550