Unsymmetrical Diaryl Sulfones and Aryl Vinyl Sulfones through Palladium-Catalyzed Coupling of Aryl and Vinyl Halides or Triflates with Sulfinic Acid Salts

Sandro Cacchi,* Giancarlo Fabrizi, Antonella Goggiamani, Luca M. Parisi and Roberta Bernini

*Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università degli Studi "La Sapienza", P. le A. Moro 5, 00185 Rome, Italy, Email: sandro.cacchiuniroma1.it

S. Cacchi, G. Fabrizi, A. Goggiamani, L. M. Parisi, R. Bernini, J. Org. Chem., 2004, 69, 5608-5614.

DOI: 10.1021/jo0493469

---

Abstract

The palladium-catalyzed reaction of sulfinic acid salts with a wide variety of aryl and vinyl halides or triflates, which is strongly influenced by the presence of nBu₄NCl, provides unsymmetrical diaryl sulfones and aryl vinyl sulfones in good yields. The use of Xantphos, a rigid bidentate ligand with a wide natural bite angle, was found to be crucial for the success of the reaction.

see article for more examples

---

---

Key Words

Diaryl Sulfones, Vinyl Sulfones, Palladium Catalysis

---

ID: J42-Y2004-640