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Accelerated asymmetric transfer hydrogenation of aromatic ketones in water

Xiaofeng Wu , Xiaoguang Li , William Hems , Frank King and Jianliang Xiao*

*Liverpool Centre for Materials and Catalysis, Department of Chemistry, University of Liverpool, Liverpool, UK L69 7ZD, Email:

X. Wu, X. Li, W. Hems, F. King, J. Xiao, Org. Biomol. Chem., 2004, 2, 1818-1821.

DOI: 10.39/b403627a


Asymmetric transfer hydrogenation of various simple aromatic ketones by the Ru-TsDPEN catalyst was shown to be feasible in aqueous HCOONa without calling for any catalyst modification, furnishing ee's of up to 95% and significantly faster rates than in the HCOOH-NEt3 azeotrope.

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On Water and in Air: Fast and Highly Chemoselective Transfer Hydrogenation of Aldehydes with Iridium Catalysts

X. Wu, J. Liu, X. Li, A. Zanotti-Gerosa, F. Hancock, D. Vinci, J. Ruan, J. Xiao, Angew. Chem. Int. Ed., 2006, 45, 6717-6722.

Asymmetric Transfer Hydrogenation in Water with a Supported Noyori-Ikariya Catalyst

X. Wu, X. Li, W. Chen, F. E. Hancock, F. King, J. Xiao, Org. Lett., 2004, 6, 3321-3324. DOI: 10.1021/ol0487175

Key Words

Transfer Hydrogenation, Reduction of Carbonyl Compounds, Ruthenium Catalysis, Formic acid

ID: J52-Y2004-680