Accelerated asymmetric transfer hydrogenation of aromatic ketones in water
Xiaofeng Wu , Xiaoguang Li , William Hems , Frank King and Jianliang Xiao*
*Liverpool Centre for Materials and Catalysis, Department of Chemistry,
University of Liverpool, Liverpool, UK L69 7ZD, Email: j.xiao
liv.ac.uk
X. Wu, X. Li, W. Hems, F. King, J. Xiao, Org. Biomol. Chem., 2004, 2, 1818-1821.
DOI: 10.1039/b403627a
Abstract
Asymmetric transfer hydrogenation of various simple aromatic ketones by the Ru-TsDPEN catalyst was shown to be feasible in aqueous HCOONa without calling for any catalyst modification, furnishing ee's of up to 95% and significantly faster rates than in the HCOOH-NEt3 azeotrope.
see article for more examples
X. Wu, J. Liu, X. Li, A. Zanotti-Gerosa, F. Hancock, D. Vinci, J. Ruan, J. Xiao, Angew. Chem. Int. Ed., 2006, 45, 6717-6722.
Asymmetric Transfer Hydrogenation in Water with a Supported Noyori-Ikariya Catalyst
X. Wu, X. Li, W. Chen, F. E. Hancock, F. King, J. Xiao, Org. Lett., 2004, 6, 3321-3324. DOI: 10.1021/ol0487175
Key Words
Transfer Hydrogenation, Reduction of Carbonyl Compounds, Ruthenium Catalysis, Formic acid
ID: J52-Y2004-680
