Organic Chemistry Portal



One-Pot Homolytic Aromatic Substitutions/HWE Olefinations under Microwave Conditions for the Formation of a Small Oxindole Library

Antje Teichert, Katja Jantos, Klaus Harms and Armido Studer*

*Fachbereich Chemie, Philipps-Universität Marburg, 35032 Marburg, Germany. Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149 Münster, Germany, Email:

A. Teichert, K. Jantos, K. Harms, A. Studer, Org. Lett., 2004, 6, 3477-3480.

DOI: 10.1021/ol048759t


A small library of α,β-unsaturated oxindoles was prepared by an efficient microwave-assisted one-pot sequence comprising an aromatic substitution followed by an ionic Horner-Wadsworth-Emmons olefination.

Preparation of Phosphonates

Preparation of Alkoxyamines

see article for more examples

Key Words

Oxindoles, Wittig-Horner Reaction, Microwave Synthesis

ID: J54-Y2004-780