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A New Ketone Synthesis by Palladium-Catalyzed Cross-Coupling Reactions of Esters with Organoboron Compounds

Hiroto Tatamidani, Fumitoshi Kakiuchi and Naoto Chatani*

*Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan, Email:

H. Tatamidani, F. Kakiuchi, N. Chatani, Org. Lett., 2004, 6, 3597-3599.

DOI: 10.1021/ol048513o (free Supporting Information)


The palladium-catalyzed coupling of 2-pyridyl esters with organoboron compounds is compatible with various functional groups and proceeds under mild reaction conditions. The coordination of the nitrogen atom to Pd is a key step for an efficient reaction.

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Key Words

Cross-Coupling, Palladium Catalysis, Aryl Ketones

ID: J54-Y2004-820