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Palladium-catalyzed α-arylation of N-protected 2-piperidinones

Arnault de Filippis, Domingo Gomez Pardo and Janine Cossy*

*Laboratoire de Chimie Organique associť au CNRS, ESPCI, 10 rue Vauquelin, 75231 Paris Cedex 05, France, Email: janine.cossyespci.fr

A. de Filippis, D. G. Pardo, J. Cossy, Tetrahedron, 2004, 60, 9757-9767.

DOI: 10.1016/j.tet.2004.06.152


Abstract

A very simple method for the α-arylation of N-protected 2-piperidinones in high yield is described. Key factors are the use of ZnCl2 and Pd(dba)2 and the nature of the base.

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Key Words

α-arylation, δ-lactams, palladium, zinc, coupling


ID: J72-Y2004-900