Palladium-catalyzed α-arylation of N-protected 2-piperidinones
Arnault de Filippis, Domingo Gomez Pardo and Janine Cossy*
*Laboratoire de Chimie Organique associé au CNRS, ESPCI, 10 rue Vauquelin,
75231 Paris Cedex 05, France, Email: janine.cossyespci.fr
A. de Filippis, D. G. Pardo, J. Cossy, Tetrahedron, 2004, 60, 9757-9767.
DOI: 10.1016/j.tet.2004.06.152
Abstract
A very simple method for the α-arylation of N-protected 2-piperidinones in high yield is described. Key factors are the use of ZnCl2 and Pd(dba)2 and the nature of the base.
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Key Words
α-arylation, δ-lactams, palladium, zinc, coupling
ID: J72-Y2004-900